ISCHIATIC ARTERY

\ˌɪskɪˈatɪk ˈɑːtəɹi], \ˌɪskɪˈatɪk ˈɑːtəɹi], \ˌɪ_s_k_ɪ__ˈa_t_ɪ_k ˈɑː_t_ə_ɹ_i]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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