TOGAVIRIDAE
\tˈɒɡɐvˌɪɹɪdˌiː], \tˈɒɡɐvˌɪɹɪdˌiː], \t_ˈɒ_ɡ_ɐ_v_ˌɪ_ɹ_ɪ_d_ˌiː]\
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A family of RNA viruses, mainly arboviruses, consisting of two genera: ALPHAVIRUS (group A arboviruses), and RUBIVIRUS. Virions are spherical, 60-70 nm in diameter, with a lipoprotein envelope tightly applied to the icosahedral nucleocapsid.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.