THIURAM D
\θˈɪjuːɹˌam dˈiː], \θˈɪjuːɹˌam dˈiː], \θ_ˈɪ_j_uː_ɹ_ˌa_m d_ˈiː]\
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A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme glutathione reductase. It has mutagenic activity and may induce chromosomal aberrations.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.