SUBSTANTIALISM

\səbstˈanʃɪəlˌɪzəm], \səbstˈanʃɪəlˌɪzəm], \s_ə_b_s_t_ˈa_n_ʃ_ɪ__ə_l_ˌɪ_z_ə_m]\
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1919 - The concise Oxford dictionary of current English
By Sir Augustus Henry

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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