ST155
\sənt wˈɒnhˈʌndɹədən fˈɪftifˈa͡ɪv], \sənt wˈɒnhˈʌndɹədən fˈɪftifˈaɪv], \s_ə_n_t w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɪ_f_t_i_f_ˈaɪ_v]\
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An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.