SECRETORY PIECE
\sˈɛkɹɪtəɹˌi pˈiːs], \sˈɛkɹɪtəɹˌi pˈiːs], \s_ˈɛ_k_ɹ_ɪ_t_ə_ɹ_ˌi p_ˈiː_s]\
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A glycoprotein found in a variety of external secretions (tears, bile, colostrum) usually complexed to secreted polymeric immunoglobulins (IMMUNOGLOBULIN A or, less frequently IMMUNOGLOBULIN M). It is derived, by proteolytic cleavage, from the polymeric immunoglobulin receptor (RECEPTORS, POLYMERIC IMMUNOGLOBULIN) and probably functions to protect the immunoglobulins from proteolysis in the secretions. (From Rosen et al., The Dictionary of Immunology, 1989)
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.