NICCOLO TOMMASEO

\nɪkˈɒlə͡ʊ tˈɒme͡ɪsɪˌə͡ʊ], \nɪkˈɒlə‍ʊ tˈɒme‍ɪsɪˌə‍ʊ], \n_ɪ_k_ˈɒ_l_əʊ t_ˈɒ_m_eɪ_s_ɪ__ˌəʊ]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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