MEMBRANE ATTACK COMPLEX
\mˈɛmbɹe͡ɪn ɐtˈak kˈɒmplɛks], \mˈɛmbɹeɪn ɐtˈak kˈɒmplɛks], \m_ˈɛ_m_b_ɹ_eɪ_n ɐ_t_ˈa_k k_ˈɒ_m_p_l_ɛ_k_s]\
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The assembly of complement plasma glycoproteins C5b, C6, C7, C8, and polymeric C9 as a group on biological membranes. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The formation of the membrane attack complex is the terminal step in the complement cascade.
By DataStellar Co., Ltd
Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.