HIRE AND PURCHASE AGREEMENT

\hˈa͡ɪ͡əɹ and pˈɜːt͡ʃɪs ɐɡɹˈiːmənt], \hˈa‍ɪ‍əɹ and pˈɜːt‍ʃɪs ɐɡɹˈiːmənt], \h_ˈaɪə_ɹ a_n_d p_ˈɜː_tʃ_ɪ_s ɐ_ɡ_ɹ_ˈiː_m_ə_n_t]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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