COGWHEEL RIGIDITY
\kˈɒɡwiːl ɹɪd͡ʒˈɪdɪti], \kˈɒɡwiːl ɹɪdʒˈɪdɪti], \k_ˈɒ_ɡ_w_iː_l ɹ_ɪ_dʒ_ˈɪ_d_ɪ_t_i]\
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Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.