CLOSTRIDIUM TETANI TOXIN
\kləstɹˈɪdi͡əm tɛtˈɑːnɪ tˈɒksɪn], \kləstɹˈɪdiəm tɛtˈɑːnɪ tˈɒksɪn], \k_l_ə_s_t_ɹ_ˈɪ_d_iə_m t_ɛ_t_ˈɑː_n_ɪ t_ˈɒ_k_s_ɪ_n]\
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The toxin elaborated by Clostridium tetani. It is a protein with a molecular weight of about 150,000, probably consisting of two fragments, tetanolysin being the hemolytic and tetanospasmin the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal convulsions.
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.