PURCHAS SAMUEL

\pˈɜːt͡ʃəz sˈamjuːl], \pˈɜːt‍ʃəz sˈamjuːl], \p_ˈɜː_tʃ_ə_z s_ˈa_m_j_uː_l]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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