PROTEASES
\pɹˈə͡ʊte͡ɪsɪz], \pɹˈəʊteɪsɪz], \p_ɹ_ˈəʊ_t_eɪ_s_ɪ_z]\
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A subclass of PEPTIDE HYDROLASES. They are classified primarily by their catalytic mechanism. Specificity is used only for identification of individual enzymes. They comprise the SERINE ENDOPEPTIDASES, EC 3.4.21; CYSTEINE ENDOPEPTIDASES, EC 3.4.22; ASPARTIC ENDOPEPTIDASES, EC 3.4.23, METALLOENDOPEPTIDASES, EC 3.4.24; and a group of enzymes yet to be assigned to any of the above sub-classes, EC 3.4.99. EC 3.4.-.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.