PERFORATED SPOT

\pˈɜːfəɹˌe͡ɪtɪd spˈɒt], \pˈɜːfəɹˌe‍ɪtɪd spˈɒt], \p_ˈɜː_f_ə_ɹ_ˌeɪ_t_ɪ_d s_p_ˈɒ_t]\
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1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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