OBSTINATENESS
\ˈɒbstɪnˌe͡ɪtnəs], \ˈɒbstɪnˌeɪtnəs], \ˈɒ_b_s_t_ɪ_n_ˌeɪ_t_n_ə_s]\
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n. Stubbornness of nature or disposition ;— pertinacity in opinion or resolution.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.