GUILTY OF
\ɡˈɪlti ɒv], \ɡˈɪlti ɒv], \ɡ_ˈɪ_l_t_i_ ɒ_v]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.